Jose Luis Medina-Franco

COMPUTER AIDED DRUG DESIGN | Assistant Member
Phone: (772) 345-4685 | Fax: (772) 345-3649 |
Jose Medina

Dr. Medina-Franco's research focuses on computer-aided drug design. The research group conducts virtual screening of large compound databases to identify novel compounds directed to targets associated with the treatment of cancer, HIV/AIDS and other diseases. Molecular modeling and chemoinformatic methods are used for the structure-based and ligand-based optimization of bioactive compounds. The group also performs structural classification, diversity analysis and data mining of chemical libraries. Current projects include:

  • Virtual screening and structure-based design of DNA methyltransferase inhibitors as anti-cancer agents
  • Computer-based discovery and development of protein kinase B inhibitors
  • Molecular modeling of a-conotoxins
  • In-silico design and profiling of combinatorial libraries
  • Structure-activity relationships studies of compound data sets using molecular similarity and other chemoinformatic approaches

Research is conducted in a multidisciplinary environment with close collaborations with experimental research groups.

COMPUTER AIDED DRUG DESIGN | Assistant Member
Phone: (772) 345-4685 | Fax: (772) 345-3649 |
Jose Medina

Dr. Medina-Franco's research focuses on computer-aided drug design. The research group conducts virtual screening of large compound databases to identify novel compounds directed to targets associated with the treatment of cancer, HIV/AIDS and other diseases. Molecular modeling and chemoinformatic methods are used for the structure-based and ligand-based optimization of bioactive compounds. The group also performs structural classification, diversity analysis and data mining of chemical libraries. Current projects include:

  • Virtual screening and structure-based design of DNA methyltransferase inhibitors as anti-cancer agents
  • Computer-based discovery and development of protein kinase B inhibitors
  • Molecular modeling of a-conotoxins
  • In-silico design and profiling of combinatorial libraries
  • Structure-activity relationships studies of compound data sets using molecular similarity and other chemoinformatic approaches

Research is conducted in a multidisciplinary environment with close collaborations with experimental research groups.

Biography

Dr. Jose Luis Medina-Franco received a Bachelor of Science in chemistry from the National Autonomous University of Mexico (UNAM) in 1998 and that same year, he joined Procter & Gamble in Mexico City, working in the research and development department. He received a Masters in Science in 2002 ("Synthesis of pyridinone-2(1H)-ones as precursors of potential HIV-1 Reverse Transcriptase Inhibitors") and a Ph.D. degree in 2005 ("Computer-Aided Drug Design. HIV-1 Reverse Transcriptase Inhibitors, Hypocholesterolemic and Antiparasitic Compounds"), both in Chemisty from UNAM, working in the laboratory of Professor Rafael Castillo. During his doctoral studies, Dr. Medina-Franco participated in research visits with Professor Jesus Jimenez-Barbero, in Madrid, Spain; Professor Alexander Tropsha at the University of North Carolina at Chapel Hill and Professor Gerald M. Maggiora at the University of Arizona. In 2005, he joined Professor Maggiora as a postdoctoral fellow. In August 2007, Dr. Medina-Franco was named Assistant Member at the Torrey Pines Institute for Molecular Studies in Florida.

Education

  • 2005 - Doctor of Philosophy (Chemistry): National Autonomous University of Mexico (UNAM), Mexico City, Mexico
  • 2002 - Master of Science (Chemistry): National Autonomous University of Mexico (UNAM), Mexico City, Mexico
  • 1998 - Bachelor of Science (Chemistry): National Autonomous University of Mexico (UNAM), Mexico City, Mexico

Positions

  • 2007 - Present: Assistant Member, Torrey Pines Institute for Molecular Studies, Port St Lucie, Florida
  • 2005 - 2007: Postdoctoral Fellow, University of Arizona, Tucson, Arizona
  • 1998 - 2000: Senior Research Associate, Procter & Gamble, Mexico City, Mexico

Professional Affiliations

  • 2007 - Present: National Researcher System, National Council of Science and Technology, Mexico
  • 2004 - Present: American Chemical Society
  • 2004 - Present: Member of the American Chemical Society, since 2004.
  • 2004 - Organizer of symposium, Rational Drug Design at XXXIX National Meeting of the Mexican Chemical Society. Merida, Mexico, October 3-7, 2004.
  • Reviewer for: Journal of Computer-Aided Molecular Design, European Journal of Pharmaceutical Sciences, Chemical Biology and Drug Design, European Journal of Medicinal Chemistry, ChemMedChem, Journal of the Mexican Chemical Society.

Selected Publications

Selected Publications (10 of 82)

  1. López-Vallejo, F.; Giulianotti, M. A.; Houghten, R. A.; Medina-Franco, J. L. Expanding the medicinally relevant chemical space with compound libraries. Drug Discovery Today 2012, 17, 718-726.
  2. Waddell, J.; Medina-Franco, J. L. Bioactivity landscape modeling: Chemoinformatic characterization of structure-activity relationships of compounds tested across multiple targets. Bioorg. Med. Chem. 2012, 20, 5443-5442.
  3. Medina-Franco, J. L.; Caulfield, T. Advances in the computational development of DNA methyltransferase inhibitors. Drug Discovery Today, 2011, 16, 418-425.
  4. Yoo, J.; Medina-Franco, J. L. Homology modeling, docking, and structure-based pharmacophore of inhibitors of DNA methyltransferase, J. Comp.-Aided Mol. Des., 2011, 25, 555-567.
  5. López-Vallejo, F.; Nefzi, A.; Bender, A.; Owen, J. R.; Nabney, I. T.; Houghten, R. A. Medina-Franco, J. L. Increased Diversity of Libraries from Libraries: Chemoinformatic Analysis of Bis-Diazacyclic Libraries. Chem. Biol. Drug Des., 2011, 77, 328-342.
  6. López-Vallejo, F.; Caulfield, T.; Martínez-Mayorga, K.; Giulianotti, M. A.; Nefzi, A.; Houghten, R. A.; Medina-Franco, J. L. Integrating Virtual Screening and Combinatorial Chemistry for Accelerated Drug Discovery. Comb. Chem. High Throughput Screening, 2011, 14, 475-487.
  7. Kuck, D.; Caulfield, T.; Lyko, F.; Medina-Franco, J. L. Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells. Mol. Cancer Ther. 2010, 9, 3016-3023.
  8. Medina-Franco, J. L.; Martínez-Mayorga, K.; Bender, A.; Marín, R. M.; Giulianotti, M. A.; Pinilla, C.; Houghten, R. A. Characterization of Activity Landscapes Using 2D and 3D Similarity Methods: Consensus Activity Cliffs. J. Chem. Inf. Model. 2009, 49, 477-491.
  9. Singh, N.; Guha, R.; Giulianotti, M.; Pinilla, C.; Houghten, R.; Medina-Franco, J. L. Chemoinformatic Analysis of Drugs, Natural Products, Molecular Libraries Small Molecule Repository and Combinatorial Libraries. J. Chem. Inf. Model. 2009, 49, 1010-1024.
  10. Medina-Franco, J. L.; Giulianotti, M. A.; Yu, Y.; Shen, L.; Yao, L.; Singh, N. Discovery of a Novel Protein Kinase B Inhibitor by Structure-Based Virtual Screening. Bioorg. Med. Chem. Lett. 2009, 19, 4634-4638.

Honors & Awards

  • Member of the National Researcher System, National Council of Science and Technology, Mexico (January 2007 – December 2009; January 2010 – December 2013).
  • Antonio Caso Medal, National Autonomous University of Mexico. Top grade average of PhD studies in Chemistry. Awarded presented in 2010.
  • Antonio Caso Medal, National Autonomous University of Mexico. Top grade average of Master in Science studies in Chemistry. Awarded presented in 2005.
  • Gabino Barreda Medal, National Autonomous University of Mexico. Top grade average of the B.S. in Chemistry. Awarded in 2000.
  • Accelrys Fellowship to the Fifth European Workshop in Drug Design, Siena, Italy, 2005.
  • Science and Technology National Council Fellowship to the University of Arizona, 2005.
  • Science and Technology National Council Fellowship at the National Autonomous University of Mexico, M.Sc. and PhD studies, 2000-2005.
  • National Autonomous University of Mexico Fellowship at the National Autonomous University of Mexico, M.Sc. and PhD studies, 2000-2005.
  • Drew University Fellowship to the 2002 Residential School on Medicinal Chemistry, New Jersey, 2002.
  • QFB Santiago Maza Award, XXXIV Pharmaceutical Sciences National Meeting, Manzanillo, Mexico, 2001.
  • Recognition Shares. Procter & Gamble, Global Home Care - Belgium. 1999.
  • National Autonomous University of Mexico Foundation Fellowship at the University of Texas at Austin, 1997.
  • Austromex Award, B.S., 1997.
  • National Autonomous University of Mexico Foundation Fellowship at the National Autonomous University of Mexico, B.S. studies, 1993-1996.