Torrey Pines Institute for Molecular Studies science image
Torrey Pines Institute for
Molecular Studies
11350 SW Village Parkway
Port St. Lucie, FL 34987-2352
USA
Scientists
Marc Giulianotti
Director of Chemistry Operations

772.345.4729 - phone
772.345.3649 - fax
contact by email

Marc Giulianotti earned his Bachelor of Science in Chemistry and Biochemistry from the University of California, San Diego in 1995 and his Masters in Business Administration from San Diego State University in 2001. Marc joined the Torrey Pines Institute as a Research Associate in 1995 and his research focused on design of novel combinatorial libraries. He held this position until 2001 and then became the Business Development Manager for Mixture Sciences, Inc., a Torrey Pines spin-off company. Marc was tapped as Directory of Chemistry Operations for the Torrey Pines Institute's Florida base in June 2007.

Research Focus

Marc Giulianotti directs a team of scientists that develops novel chemistry methods, including combinatorial and computation chemistry, for rapidly identifying lead compounds and clinical candidates for a variety of indications such as pain management, cancer, central nervous system disorders, and HIV/AIDS.

Publications

  1. Sospedra, M, Zhao, Y, Giulianotti, M, Simon, R, Pinilla, C, Martin, R. Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones. J Immunol Methods. Epub Dec 28, 2009. [Epub ahead of print]
  2. Yongye, AB, Li, Y, Giulianotti, MA, Yu, Y, Houghten, RA, Martínez-Mayorga, K. Modeling of Peptides Containing D-Amino Acids: Implications on Cyclization. J Comput Aided Mol Des. 23(9):677-89, 2009.
  3. Li, Y, Yongye, BA, Giulianotti, MA, Martínez-Mayorga, K, Yu, Y, Houghten, RA. Synthesis of Cyclic Peptide through Direct Aminolysis of a Peptide Thioester in an Aqueous Organic Solvent. J Comb Chem. Epub Oct 6, 2009. [Epub ahead of print]
  4. Medina-Franco, JL, Giulianotti, MA, Yu, Y, Shen, L, Yao, L, Singh, N. Discovery of a novel protein kinase B inhibitor by structure-based virtual screening. Bioorg Med Chem Lett. 19(16):4634-8, 2009.
  5. Li, Y, Giulianotti, M, Houghten, RA. Solid phase synthesis of 2-alkylidene-6-alkyl-imidazo [2, 1-b] thiazole- 3, 5[2H, 6H]-dione derivatives. Tetrahedron Letters. 50(42):5857-9, 2009.
  6. Li, Y., Yu, Y., Giulianotti, M., Houghten, R.A. One-Pot High-Throughput Synthesis of beta-Turn Cyclic Peptidomimetics via "Volatilizable" Supports. J. Org. Chem. Epub Jan 27, 2009. [Epub ahead of print.]
  7. Medina-Franco, J.L., Martínez-Mayorga, K., Bender, A., Marín, R.M., Giulianotti, M.A., Pinilla, C., Houghten, R.A. Characterization of Activity Landscapes Using 2D and 3D Similarity Methods: Consensus Activity Cliffs. J. Chem. Inf. Model. 49:477-91, 2009.
  8. Singh, N., Guha, R., Giulianotti, M., Pinilla, C., Houghten, R., Medina-Franco, J.L. Chemoinformatic Analysis of Combinatorial Libraries, Drugs, Natural Products, and Molecular Libraries Small Molecule Repository. J. Chem. Inf. Model. 49(4):1010-24. Epub Mar 20, 2009.
  9. Yongye, A.B., Appel, J.R., Giulianotti, M.A., Dooley, C.T., Medina-Franco, J.L., Nefzi, A., Houghten, R.A., Martínez-Mayorga, K. Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. Bioorg. Med. Chem. Epub Jun 21, 2009. [Epub ahead of print.]
  10. Li, Y., Yu, Y., Giulianotti, M., Houghten, R.A. High throughput synthesis of peptide alpha-thioesters through the use of "volatilizable" support. J. Comb. Chem. 10(5):613-6, 2008. Epub Aug 19, 2008.
  11. Martinez-Mayorga, K., Medina-Franco, J., Giulianotti, M.A., Pinilla, C., Dooley, C.T., Appel, J.R. and Houghten, R.A. Conformation-Opioid Activity Relationships of Bicyclic Guanidines from 3D Similarity Analysis. Bioorg. Med. Chem. 16(11):5932-5938, 2008. Epub Apr 27, 2008.
  12. Medina-Franco, J.L., Martínez-Mayorga, K., Giulianotti, M.A., Houghten, R.A., Pinilla, C. Visualization of the Chemical Space in Drug Discovery. Curr.Comput.Aided Drug Des. 4:323-334, 2008.
  13. Houghten, R.A., Pinilla, C., Giulianotti, M.A., Appel, J.R., Dooley, C.T., Nefzi, A., Ostresh, J.M., Yu, Y., Maggiora, G.M., Medina-Franco, J.L., Brunner, D. and Schneider, J. Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvultion by computational methods. J. of Comb.Chem. 10 (1):3-19, 2007.
  14. Medina-Franco, J. L.; Maggiora, G. M.; Giulianotti, M. A.; Pinilla, C.; Houghten, R. A. A similarity-based data-fusion approach to the visual characterization and comparison of compound databases. Chem. Biol. Drug Des. 70(5):393-412, 2007.
  15. Medina-Franco, J.L., Maggiora, G.M., Giulianotti, M., Pinilla, C., Houghen, R.A. A Similarity-based Data-fusion Approach to the Visual Characterization and Comparison of Compound Databases. Chem. Biol. Drug Des. 70:393-412, 2007.
  16. Sospedra, M., Muraro, P., Stefanova, I., Zhao, Y., Chung, K., Li, Y., Giulianotti, M., Simon, R., Mariuzza, R., Pinilla, C., Martin, R. Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype. J. Immunol. 36:1951-1961, 2006.
  17. Giulianotti, M., Nefzi, A. Efficient approach for the diversity-oriented synthesis of macro-heterocycles on solid-support Tetrahedron Letters 44:5307–5309, 2003.
  18. Nefzi, A., Giulianotti, M., Truong, L., Rattan, S., Ostresh, J.M., Houghten, R.A. Solid phase synthesis of linear ureas tethered to hydantoins and thiohydantoins. J. Comb. Chem. 4:175-178, 2002.
  19. Pinilla, C., Giulianotti, M., Houghten, R. How to screen trillions of drug candidate compounds SP2 June:36-37, 2002.
  20. Pinilla, C., Giulianotti, M., Houghten, R. Mixed libraries speed up HTS even further SP2 August:18-19, 2002.
  21. Nefzi, A., Giulianotti, M.A., Houghten, R.A. Solid-phase synthesis of bis-heterocyclic compounds from resin-bound orthogonally protected lysine. J. Comb. Chem. 3:68-70, 2001.
  22. Nefzi, A., Giulianotti, M.A., Ong, N.A., Ostresh, J.M., Dooley, C.T., Blondelle, S.E., Houghten, R.A. Solid phase synthesis of acyclic and heterocyclic combinatorial libraries from resin-bound triamines. In: Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries 2000 (Epton, R., Ed.), Mayflower Worldwide, Birmingham, UK, pp. 119-122, 2001.
  23. Nefzi, A., Giulianotti, M.A., Houghten, R.A. Solid-phase synthesis of substituted 2,3-diketopiperazines from reduced polyamides. Tetrahedron 56:3319-3326, 2000.
  24. Nefzi, A., Giulianotti, M.A., Houghten, R.A. Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones. Tetrahedron Lett. 41:2283-2287, 2000.
  25. Nefzi, A., Giulianotti, M.A., Ong, N.A., Houghten, R.A. Solid-phase synthesis of bis-2-imidazolidines from resin-bound tripeptides. Org. Letters 2:3349-3350, 2000.
  26. Nefzi, A., Giulianotti, M.A., Ong, N.A., Houghten, R.A. Combinatorial chemistry: Solid-phase synthesis of heterocyclic compounds from Cα-functionalized amino acids. In: Peptides for the New Millenium, Proceedings of the 16th American Peptide Symposium (Fields, G.B., Tam, J.P., Barany, G., Eds.), Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 189-190, 2000.
  27. Ostresh, J.M., Schoner, C.C., Hamashin, V.T., Giulianotti, M.A., Nefzi, A., Kurth, M.J., Houghten, R.A. Solid phase synthesis of heterocyclic combinatorial libraries derived from peptides. In: Peptides, Biology and Chemistry, Proceedings of the 1998 Chinese Peptide Symposium (Hu, Y.J., Wang, R., and Tam, J.P., Eds.), Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 192-197, 2000.
  28. Houghten, R.A., Dooley, C.T., Giulianotti, M.A., Hamashin, V.T., Schoner, C., Ostresh, J.M., Nefzi, A. Solid phase synthesis of heterocyclic positional scanning combinatorial libraries. In: Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries 1998 (Epton, R., Ed.), Mayflower Worldwide Ltd., Birmingham,UK, pp. 11-14, 1999.
  29. Meyer, J.-P., Ostresh, J.M., Nefzi, A., Hamashin, V.T., Schoner, C.C., Giulianotti, M.A., Hannah, A.L., Houghten, R.A. Peptides as precursors in the synthesis of heterocyclic positional scanning combinatorial libraries. In: Peptides, Frontiers of Peptide Science, Proceedings of the 15th American Peptide Symposium (Tam, J.P. and Kaumaya, P.T.P., Eds.), Kluwer, Dordrecht, The Netherlands, pp. 25-27, 1999.
  30. Nefzi, A., Giulianotti, M.A., Houghten, R.A. Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids. Tetrahedron Lett. 40:8539-8542, 1999.
  31. Nefzi, A., Ong, N.A., Giulianotti, M.A., Ostresh, J.M., Houghten, R.A. Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives. Tetrahedron Lett. 40:4939-4942, 1999.
  32. Nefzi, A., Ostresh, J.M., Giulianotti, M.A., Houghten, R.A. Solid-phase synthesis of trisubstituted 2-imidazolidones and 2-imidazolidinethiones. J. Comb. Chem. 1:195-198, 1999.
  33. Ostresh, J.M., Schoner, C.C., Giulianotti, M.A., Kurth, M.J., Houghten, R.A. Combinatorial libraries: equimolar incorporation of benzaldehyde mixtures in reductive alkylation reactions. In: Peptides, Frontiers of Peptide Science, Proceedings of the 15th American Peptide Symposium (Tam, J.P. and Kaumaya, P.T.P., Eds.), Kluwer, Dordrecht, The Netherlands, pp. 57-58, 1999.
  34. Nefzi, A., Giulianotti, M., Houghten, R.A. Solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones. Tetrahedron Lett. 39:3671-3674, 1998.
  35. Nefzi, A., Giulianotti, M.A., Brehm, E., Schoner, C.C., Hamashin, V.T., Houghten, R.A. Synthesis of cyclic ureas and cyclic thioureas from acyl dipeptides. In: Peptides: Frontiers of Peptide Science, Proceedings of the Fifteenth American Peptide Symposium (Tam, J. P., Kaumaya, P. T. P., Eds.) Kluwer Academic Publishers, Dordrecht, The Netherlands, pp. 265-266, 1998.
  36. Nefzi, A., Ostresh, J.M., Giulianotti, M.A., Houghten, R.A. Efficient solid phase synthesis of 3,5-disubstituted hydantoins. Tetrahedron Lett. 39:8199-8202, 1998.
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